- Andonova, T. , Muhovski, Y. , Apostolova, E. , Naimov, S. , Mladenova, S. , Slavov, I. , Dincheva, I. , Georgiev, V. , Pavlov, A. & Dimitrova-Dyulgerova, I. (2024). DNA protective, antioxidant and anti-carcinogenic potential of Meadowsweet (Filipendula ulmaria) dry tincture. Antioxidants, 13:
| Type | Journal Article |
|---|---|
| Year | 2024 |
| Title | DNA protective, antioxidant and anti-carcinogenic potential of Meadowsweet (Filipendula ulmaria) dry tincture |
| Abstract | Nowadays, the interest in natural antioxidants (especially phenolics) for the prevention of oxidative stress-related diseases is increasing due to their fewer side effects and more potent activity than some of their synthetic analogues. New chemical and pharmacological studies of well-known herbal substances are among the current trends in medicinal plant research. Meadowsweet (Filipendula ulmaria) is a popular herb used in traditional medicine to treat various diseases (antirheumatic, in-flammatory, tumor prevention etc.). Dry tincture of Filipendulae ulmariae herba, collected from the Bulgarian flora, was analyzed by HPLC method and bioassayed for activities - antioxidant, anti-proliferative and DNA-protective against oxidative damage. The HPLC phenolic profile showed 12 phenolics, of which salicylic acid (18.84 mg/g dry extract), rutin (9.97 mg/g de), p-coumaric acid (6.80 mg/g de), quercetin (4.47 mg/g de), rosmarinic acid (4.01 mg/g de), and vanillic acid (3.82 mg/g de) were the major components. The high antioxidant potential of the species was confirmed by using four methods, best expressed in CUPRAC assay (10 605.91 μM TE/g de). The present study reports for the first time а high protection against oxidative DNA damage and an antiproliferative effect against hepatocellular carcinoma (HepG2 cell line). Meadowsweet dry tincture possesses a high potential to prevent diseases caused by oxidative stress. |
| Journal | Antioxidants |
| Volume | 13 |
| Date | 30 September 2024 |
| Endnote keywords | Filipendulae ulmariae herba, dry tincture, phenolic profile (HPLC), in vitro antioxidant, DNA pro-tective, and antiproliferative activities |
| Authors | Andonova, T. , Muhovski, Y. , Apostolova, E. , Naimov, S. , Mladenova, S. , Slavov, I. , Dincheva, I. , Georgiev, V. , Pavlov, A. & Dimitrova-Dyulgerova, I. |